How many Americans die from carbon monoxide poisoning each year? More than 400 Americans die from unintentional carbon monoxide poisoning each year (not linked to fires). Additionally, there are more than 20,000 emergency room visits and 4,000 hospitalizations linked to carbon monoxide poisoning. By ProMatcher Staff Updated: 08/08/2016 Next Question Source: CDC Next Question Find Local Pros Free Actuaries Cost Estimates Related Questions How many injuries involve vacuum cleaners? How Many Forklift Injuries Occur Each Year? How many people are killed by wood chippers? How many flooring-related injuries occur each year? How many home fires occur each year?